The game is said to not include micro transactions and may re-use content cut from the original game while removing criticized aspects from the original game. Improvements to the atmosphere are also being made by bringing new 3D audio technology as well as the dismemberment system with more gore effects. Assets are remade from scratch while also reusing some original ones, such as the audio. With the power of next generation hardware, the developers are said to be able to expand more areas with more ways than what was technically being limited in 2008 during the original game's launch, while trying to keep the vision for the game the same. It is also the first game not developed by Visceral Games after their disbanding and a first main game in the series not developed for the Xbox 360 and Playstation 3.

It is the first game in the franchise to be announced after a hiatus of 8 years since the release date of Dead Space 3 and its DLC, not considering the scrapped Dead Space 4 project. The game is rumored to be inspired by Capcom's 2019 Resident Evil 2: Remake, to which, likewise, Resident Evil 4 was also one of the inspirations for the original 2008 game. Prior to the official announcement, numerous leakers came forward with a rumored Dead Space remake in the works at EA, and that the studio behind the 2020 video game Star Wars: Squadrons would be making it for the Frostbite engine. Brute: A massive Necromorph often considered as a sub-boss in the Dead Space franchise.Slasher: The most common form of Necromorph, It attacks using sharp mutated blades sprouting from the victims' torso.

Nicole Brennan: Isaac's girlfriend, who accepted a job offer to serve as a medical officer on the USG Ishimura after Isaac coaxed her to do so, saying she would regret losing the chance to have it in her resumé.

He is sent to answer a distress call from the USG Ishimura.

Zach Hammond: The leader of the Isaac's team also responsible for the team's security.

Kendra Daniels: A computer specialist of unknown background, appointed to the mission by a CEC superior.

Isaac Clarke: A CEC engineer who went to answer the distress call from the USG Ishimura and got far more than he bargained for.

The game brings back Isaac Clarke as the protagonist, surviving the Necromorph outbreak on the USG Ishimura.

Game dead space